General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF ACECLOFENAC, PARACETAMOL 

Introduction


Aceclofenac is a non-steroidal anti-inflammatory product. Paracetamol has analgesic & antipyretic activity. It is a weak inflammatory product. Aceclofenac generally works to inhibit the synthesis of the inflammatory cytokines interleukin -1b & tumor necrosis factor. It also inhibits the production of prostaglandins (E2). 

Class NSAID’s & Analgesic & Antipyretic.

Pharmacokinetics 

Absorption Aceclofenac has 100% bioavailability. It is rapidly absorbed.

Paracetamol is well absorbed when it is taken orally.

Distribution Aceclofenac bound to plasma proteins more than 99.7%

Paracetamol distribute all over the fluid in the body, proteins binding-25%

Plasma-elimination half-life of Aceclofenac-4-4.3 hours

 Plasma-elimination half-life of Paracetamol-1-4 hours

Mechanism of action

The mechanism of action of Aceclofenac is to inhibit the functioning of Cyclo-oxygenase enzyme which is a catalyst (increases rate of reaction) for the synthesis of prostaglandins which is involved for the contribution of inflammatory cells response & for pain also. 

Paracetamol works by two mechanisms of action as Analgesic by greater the pain threshold level & Antipyretic as inhibiting the effect of endogenous pyrogen by acting on thermoregulatory center in the hypothalamus. 

Pharmacological uses of Aceclofenac & Paracetamol 

This combination is used as for a toothache, muscle pain, fever, cold, bones & joint pain, swelling, migraine, Rheumatoid arthritis, Ankylosing spondylitis, Post-operative pain, menstrual pain etc. 

Side Effects of Aceclofenac & Paracetamol

The adverse effects of aceclofenac & paracetamol are- 

Nausea, allergic reaction

Skin rashes, diarrhea 

Fluid retention, congestive heart failure, 

Liver failure

Contraindication Aceclofenac & Paracetamol should be avoided to a pregnant woman because of the risk of having a patent ductus arteriosus in the neonate.

product Interaction 

Atenolol (its anti-hypertensive action decreases) 

Chlorthalidone (therapeutic effects decreases) 

Diuretics (their effects decreased by the Aceclofenac) 

Cyclosporin (its nephrotoxicity increases) 

Dosage

Each tablet contains Aceclofenac 100 mg & Paracetamol 500 mg. The dose recommended is 1 tablet twice a day (BD) in the morning and in the evening, max 2 tablets. Don’t take Aceclofenac & Paracetamol without doctor’s prescription. 

We are the supplier of ACECLOFENAC & PARACETAMOL & also a trader of ACECLOFENAC & PARACETAMOL.

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ACECLOFENAC 100mg, PARACETAMOL 325mg Tablet ALU-ALU 10*10