PHARMA THIRD PARTY CONTRACT MANUFACTURER OF AMLODIPINE BESYLATE (orally-tablet)
Amlodipine Besylate is a part of the family calcium channel blocker for lowering the blood pressure in hypertension. They work to lessen the workload (pump) of Heart by relaxing the blood vessels & are a long-acting product. It increases the input of blood to the heart to suppress the chest pain.
Class Calcium channel blocker
Mechanism of Action
Amlodipine works on the principle of blocking the calcium ion influx across the cell membrane on vascular smooth muscle cells with a greater effect as compared to cardiac muscle cells. As a result, vasodilatation occurs & peripheral vascular resistance decreases to lower the blood pressure.
Absorption-Slowly but completely absorbed from GIT.
Bioavailability of Amlodipine-64-90%
Protein binding of Amlodipine-97.5%
A half-life of Amlodipine-30-50 hours
Amlodipine is used for the management of high blood pressure, coronary artery disease, Heart-related chest pain, chronic stable angina, Vasospastic angina, Prevent Strokes.
Swelling of legs & feet
Dizziness & Drowsiness
Worsening chest pain
There are a number of products which can interact with the Amlodipine
Alprenolol, Acebutolol (its hypotensive action increases)
Alfuzosin, Amphetamine (increases hypotensive action)
Amphotericin B, Amorolfine (adverse effects)
Barbexaclone, Barbital (Increases metabolism)
Starting dose-5mg OD (once a day)
Maintaining does-5-10mg OD (once a day)
The dose should not exceed 10mg per day. For the fragile patient, 2.5mg is enough.
We are the supplier of Amlodipine & also a trader of Amlodipine.
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