Cardiac/Diabetic Products

CONTRACT MANUFACTURER OF AMLODIPINE & ATENOLOL 

Introduction


Amlodipine & Atenolol combination possesses Antihypertensive activity. Amlodipine act as dihydropyridine Calcium Channel Blocker & Atenolol a Cardio selective Beta-blocker. 

Class 

Class belongs to this combination of product is beta blocker & Calcium Channel Blocker.

Mechanism of Action

Atenolol provides negative chronotropic & negative inotropic effects on the heart, so that decreases oxygen consumption, cardiac work & aortic pressure. Atenolol increases oxygen supply & exercise tolerance in angina patients and decreases BP in hypertensive patients. Amlodipine work as to block the influx of Ca2+ ions through Voltage-gated L-type Calcium Channels to the peripheral vascular smooth muscle cells.

Pharmacokinetics 

Absorption- Amlodipine plasma peak level is 6-12 hours (oral administrations)

Atenolol plasma peak level is 2-4 hours (oral administrations)

Distribution-Amlodipine bound to plasma proteins is 93%

Bioavailability of Amlodipine 64-90%

Atenolol bound to plasma proteins is 6-16%

A half-life of Amlodipine 30-50 hours and of Atenolol 6-7 hours

Pharmacological Uses of Amlodipine & Atenolol

As this combination has antihypertensive action, therefore, is used to lower the high blood pressure (hypertension) & thereby decrease the probability of heart problems, strokes. It helps to get relief from the chest pain (angina) & chronic stable angina.

Side Effects

The side effects of Amlodipine & Atenolol are

A headache, dizziness & breathlessness

Fatigue & muscle cramps

Bradycardia, Oedema

Dyspepsia & Dyspnoea

Cold extremities

Contraindicated during pregnancy & should not be provided to a lactating mother.

product Interactions 

The product which can Interact/ interfere with this combination is Clonidine. The other products are Cyclosporine, Diazepam, Ethinyl estradiol and Clomipramine. 

Dosage

Each tablet contains Atenolol 25 or 50 mg & Amlodipine 5 mg. The dose recommended is 1 tablet per day or might be 2 tablets per day (as per doctor’s recommendation). Always consult with your Doctor or Pharmacist before taking Amlodipine & Atenolol.

We are the supplier of Amlodipine & Atenolol & also a trader of Amlodipine & Atenolol.

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ATENOLOL 50mg, AMLODIPINE BESYLATE 5mg Tablet ALU-ALU 10*10