Cardiac/Diabetic Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF ATORVASTATIN

Introduction

Atorvastatin is categorized under HMG CoA reeducates inhibitors that are the family of statins. Atorvastatin is the only product in its class specifically indicated for lowering both elevated LDL-Cholesterol (LDL-low density lipoproteins) & Triglycerides in patients with hypercholesterolemia. It helps to increase the good cholesterol (HDL-High density lipoproteins).

Class Statins

Mechanism of action

Atorvastatin action for lowering bad cholesterol is shown by inhibiting HMG CoA reductase enzyme which is essential for the reduction conversion of HMG CoA to mevalonate, which is necessary for the hepatic cholesterol biosynthesis. Thus decreases the bad cholesterol synthesis. 

Pharmacokinetics

Absorption-Atorvastatin-rapidly absorbed after taken orally

Bioavailability of Atorvastatin-14%

Protein binding of Atorvastatin-98%

The half-life of Atorvastatin-14 hours, HMG CoA inhibitors-20-30 hours. 

Pharmacological Uses

Atorvastatin can be used in the management of High cholesterol (Hypercholesterolemia), atherosclerotic stroke, coronary atherosclerosis and prevention of heart attack, Cardiac disease, and Dyslipidemia & Heart complications & also minimizes the risk of heart attack.



Side Effects

Joint pain

Reversible myositis

Myopathy 

Type-2 diabetes mellitus

Persistent liver enzyme abnormalities 

Diarrhea & Nausea

product Interactions

Acetaminophen (side effects increases)

Acetazolamide (side effects increases)

Aliskiren (serum concentration increases)

Almasilate, Aluminum (serum concentration decreases)

Amiodarone (decreases metabolism)

Dosage-

Adult- 10-80 mg PO q day, Children- 0-80 mg PO q day.



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ATORVASTATIN 10mg Tablet ALU-ALU 10*10