Antibiotics Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF CEFPODOXIME & POTASSIUM CLAVULANATE

Introduction

Cefpodoxime is a Third- Generation Cephalosporin antibiotic & Potassium Clavulanate or Clavulanic acid is a beta-lactam antibiotic. The motive for the formulation of this combination is that these are not effective individually as an antibiotic. Clavulanic acid enhances his antibiotic nature when combined with Penicillin group antibiotics.

Antibacterial spectrum the combination is broad-spectrum.

Mechanism of action 

The combination possesses bactericidal activity. Cefpodoxime inhibits the bacteria’s cell wall biosynthesis to stop the growth of bacteria & to reduce the development of product-resistant bacteria & Clavulanic acid is a beta-lactamase inhibitor & has a similar structure as that of penicillin.

Pharmacokinetics 

Bioavailability of cefpodoxime- 50%

Plasma protein binding of cefpodoxime-20-30%

Plasma protein binding of Clavulanic acid-20-30%

Elimination Half-life of Cefpodoxime -2-3 hours

Elimination Half-life of Clavulanic acid -2-3 hours

Pharmacological uses- Cefpodoxime & Clavulanic acid/potassium Clavulanate can be prescribed in following kinds of infection Upper & Lower Respiratory Tract Infection, Urinary Tract Infection, Otitis Media, and Skin Infections, General gonorrhea, acute maxillary sinusitis & Tonsillitis.

Side effects of Cefpodoxime & Potassium clavulanate adverse effects of this combination are 

Allergic reactions

Skin rash, redness 

Blistering, weak or tired

Upset stomach & nausea

Diarrhea, gassiness & discomfort

A headache & irritation

product Interaction The products which can interfere with the action of Cefpodoxime & Potassium clavulanate are

Aluminum

Amoxicillin 

Antacids

H2 receptor inhibitors

Oral contraceptives

Dosage-

100-200 mg of cefpodoxime & clavulanic acid every 12 hours i.e. 1 tablet twice a day. For children- 8=10 mg/kg per day in two divided doses.

We are the supplier of Cefpodoxime & Potassium clavulanate & also a trader of Cefpodoxime & Potassium clavulanate.

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