Antibiotics Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF CEFUROXIME AXETIL & POTASSIUM CLAVULANATE

Introduction


Cefuroxime is a semi-synthetic beta-lactamase resistant, second- Generation Cephalosporin antibiotic & is used as a proproduct which after metabolizing converted into its active form which is Cefuroxime. Clavulanic acid/potassium clavulanate is beta-lactamase inhibitor which is used to enhance the anti bactericidal activity of Cefuroxime.

Antibacterial-Spectrum of this product is a broad-spectrum product & active against gram-positive- streptococcus & Gram negative- E.Coli.

Mechanism of action 

As Cefuroxime has bactericidal action (kill/destruction of bacteria) it will inhibit the synthesis of the cell wall of bacteria thereby stop the growth of bacteria as a result of which infection-causing bacteria will die. Potassium clavulanate/clavulanic acid is itself a beta-lactamase inhibitor although it has less antimicrobial activity but is added in this combination to prevent the destruction of Cefuroxime.

Pharmacokinetics 

Bioavailability- Cefuroxime-67.9%

The serum half-life of cefuroxime is -1.2 hours.

Protein binding is 50% & is rapidly hydrolyzed

Pharmacological uses Cefuroxime & potassium clavulanate can be prescribed in infection caused by bacteria, the indications are Respiratory tract infections, Otitis media, Pharyngitis, Sinusitis, Bronchitis, Urinary Tract Infections (UTI), and Lyme disease & Impetigo. 

Side effects of Cefuroxime & Potassium clavulanate 

The adverse effect of this combination is- 

Nausea, Vomiting

Epidermal necrosis 

Anaphylaxis

Nephrotoxicity 

Jarisch-Herxheimer Reaction

Accumulation of gas

Dizziness & drowsiness

product interaction 

Probenecid decreases renal clearance of Cefuroxime. 

Nephrotoxicity with Aminoglycosides & Furosemide.

Dosage- Oral tablet & suspension is available in this product. 500 mg of Cefuroxime & 125 mg of Clavulanic acid. 

We are the supplier of CEFUROXIME & POTASSIUM CLAVULANATE & also a trader of CEFUROXIME & POTASSIUM CLAVULANATE.

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CEFUROXIME AXETIL 500mg, CLAVULANIC ACID 125mg Tablet ALU-ALU 10*10