PHARMA THIRD PARTY CONTRACT MANUFACTURER OF ACECLOFENAC, PARACETAMOL & CHLORZOXAZONE
Aceclofenac- A non-steroidal anti-inflammatory product which is a derivative of diclofenac family
Paracetamol- An analgesic and antipyretic product which is a derivative of acetanilide
Chlorzoxazone- A centrally acting muscle-relaxant
Mechanism of action
Aceclofenac and Chlorzoxazone both work with the same mechanism as they both are an obstacle but their target is different as Aceclofenac work against cyclooxygenase enzyme and Chlorzoxazone against the nerve impulses that transmit signals to the brain.
The combination absorbed rapidly & completely after oral administration. The Onset of Action for Paracetamol is 30 - 60 minutes & for Chlorzoxazone is 1 hour. The Bioavailability of Aceclofenac is 100% and of Paracetamol is 60-70%. The Protein binding of Paracetamol is 25% & Half-life 1-4 hours and Protein binding of Aceclofenac is 99% and Half-life is 4 hours.
The therapeutic uses a combination of Aceclofenac, Paracetamol & chlorzoxazone
Pain & inflammation
Low back pain
Spondylitis & Rheumatoid arthritis
The following are the side effects associated with this combination Heartburn, nausea, Drowsiness, dizziness, Excitement, restlessness & irritability, Jaundice & diarrhea, Gastrointestinal bleeding & coagulation disorder.
Lithium & digoxin their plasma concentration increases and the CNS (central nervous system) depressants can cause CNS depression with the products.
Adults: 1 tablet to be taken 1-3 times a day after meals or as recommended by tour Doctor or Pharmacist.
We are the supplier of Aceclofenac, Paracetamol & chlorzoxazone & also a trader of Aceclofenac, Paracetamol & chlorzoxazone.
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