General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF ACECLOFENAC, PARACETAMOL & CHLORZOXAZONE

Introduction-  
  

Aceclofenac- A non-steroidal anti-inflammatory product which is a derivative of diclofenac family

Paracetamol- An analgesic and antipyretic product which is a derivative of acetanilide

Chlorzoxazone- A centrally acting muscle-relaxant 

Mechanism of action   

Aceclofenac and Chlorzoxazone both work with the same mechanism as they both are an obstacle but their target is different as Aceclofenac work against cyclooxygenase enzyme and Chlorzoxazone against the nerve impulses that transmit signals to the brain. 

Pharmacokinetic

The combination absorbed rapidly & completely after oral administration. The Onset of Action for Paracetamol is 30 - 60 minutes & for Chlorzoxazone is 1 hour. The Bioavailability of Aceclofenac is 100% and of Paracetamol is 60-70%. The Protein binding of Paracetamol is 25% & Half-life 1-4 hours and Protein binding of Aceclofenac is 99% and Half-life is 4 hours. 

Pharmacological Uses

The therapeutic uses a combination of Aceclofenac, Paracetamol & chlorzoxazone

Pain & inflammation

Muscle-relaxant

Low back pain

Cervical pain

Post-traumatic pain

Spondylitis & Rheumatoid arthritis

Side Effects

The following are the side effects associated with this combination Heartburn, nausea, Drowsiness, dizziness, Excitement, restlessness & irritability, Jaundice & diarrhea, Gastrointestinal bleeding & coagulation disorder. 

product Interactions

Lithium & digoxin their plasma concentration increases and the CNS (central nervous system) depressants can cause CNS depression with the products. 

Dosage

Adults: 1 tablet to be taken 1-3 times a day after meals or as recommended by tour Doctor or Pharmacist.

We are the supplier of Aceclofenac, Paracetamol & chlorzoxazone & also a trader of Aceclofenac, Paracetamol & chlorzoxazone.

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CHLORZOXAZONE 250mg, PARACETAMOL 325mg, ACECLOFENAC 100mg Tablet Blister 10*10