PHARMA THIRD PARTY CONTRACT MANUFACTURER OF DICLOFENAC POTASSIUM & PARACETAMOL
NSAIDs (Non-steroidal anti-inflammatory products) are the class which includes painkillers, analgesic, & antipyretic. Diclofenac is a NSAID & has anti-inflammatory & analgesic action & Paracetamol has analgesic & antipyretic effects. When it comes in combination, the effect of these products get enhanced & provides more relief from fever & pain.
Analgesic (Non-Opioid) & Antipyretic, Non-Steroidal Anti-Inflammatory products (NSAIDs).
Mechanism of Action
The Diclofenac works by inhibiting the cyclooxygenase enzyme (COX-2) which works as an important material/ingredient for the formation of prostaglandin which promotes to inflammation. In this mechanism of action, of this combination paracetamol will show its action first so that patient can get relief from pain & Diclofenac will show its effect after paracetamol.
Absorption-product absorbed completely
Bioavailability of Diclofenac-50%
The onset of action of the product is 30-60 min
Duration of action of the product is 6-12hrs
Plasma protein binding- Diclofenac- less than 99%
Plasma protein binding-Paracetamol-less than 20%
The half-life of Diclofenac-2 hours
The half-life of Paracetamol-1-4 hours
Diclofenac potassium & paracetamol can be prescribed in Joint & muscular pain, Inflammation of the eye, Post-operative pain, Ankylosing spondylitis, Menstrual pain, Dental Pain, Sports injuries & Joint stiffness by arthritis.
Side Effects of Diclofenac potassium & paracetamol
Epigastric pain Bronchospasm
Prolonged bleeding time
The product which can interrupt with the therapeutic action of Diclofenac potassium & paracetamol are
Potentiates potassium-sparing diuretics
Angiotensin II receptor blockers
Each tablet contains diclofenac sodium 50 mg & paracetamol 500 mg,
The Dose recommended is thrice a day or as directed by Doctor/pharmacist.
We are the supplier Diclofenac potassium & paracetamol & also a trader of Diclofenac potassium & paracetamol.
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