PHARMA THIRD PARTY CONTRACT MANUFACTURER OF PROPRANOLOL HCl, FLUNARIZINE
This combination is designed in a way that it is the first line product in the migraine prophylaxis as one product blocks the beta entry and other calcium entry. Propranolol is a beta-blocker used in cardio as well as neurological disorder. Flunarizine functions as calcium channel blocker and histamine blockers.
Beta and calcium blockers
Mechanism of action
Propranolol functions by inhibiting the action of adrenaline and noradrenaline at their respective receptors that is beta-1 and beta-2 adrenergic receptor. Flunarizine shows its action by blocking the entry of calcium ions and also histamine action.
Both these products highly bound to plasma proteins as Propranolol more than 90% and Flunarizine up to 99% and both products metabolized through a hepatic mechanism. The total half-life of Propranolol and Flunarizine 4 hours and -18 days respectively. Propranolol mostly metabolized excreted in urine.
The combination of these two products with the different therapeutic action may be prescribed in vertigo, Migraine pain, Fast heart rate, occlusive peripheral vascular disease and migraine prophylaxis.
There is the number of products which can interact with the functioning of Propranolol and Flunarizine, few of them are Diazepam, Cimetidine, Diltiazem, Salbutamol, Theophylline, Methyldopa, verapamil and thyroid hormones.
We are the supplier of Propranolol and Flunarizine & also a trader of Propranolol and Flunarizine.
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