PHARMA THIRD PARTY CONTRACT MANUFACTURER OF METFORMIN & GLICLAZIDE
Metformin & Gliclazide is the combination of two oral antihyperglycemic products which is used to cure Type-2 diabetes (Non-insulin dependent diabetes mellitus). Metformin belongs to the Biguanides class & Gliclazide belongs to the sulfonylurea class.
Mechanism of Action
Gliclazide & Metformin acts ac reducing the blood sugar level that is glucose released from the liver (which increases in diabetes) & this combination stimulates the secretion of insulin from the pancreatic beta cells & Inhibits Platelet Aggregation.
Absorption of Metformin -absorbed from GI tract
Bioavailability of Metformin-50-60%
Duration of action- approx. 12 hours
Protein-Binding of Metformin-negligible bound to plasma protein
Protein-Binding of Gliclazide: 94%
Elimination- 10-12 hours
A half-life of Metformin-6.2 hours
A half-life of Gliclazide-10.4 hours
The combination of these two Antidiabetic products are used in the treatment of type-2 diabetes (Non-insulin dependent), Control blood sugar level which prevents Kidney damage, Blindness, Nerve problems & Sexual function problems & Loss of limbs.
Skin Reaction, Leucopenia
Vomiting, Diarrhoea, Gastritis
The combination may interact with
Alcohol (causes nausea & flushing)
Salicylates, Phenylbutazone, Clofibrate, Sulphonamides, Oral Anticoagulants and MAOIs (increase the effect)
Rifampicin, Barbiturates, Alcohol, Diuretics, Diazoxide, Corticosteroids, Β-Blockers, Oestrogens (decrease the effect)
As recommended by your Doctor or pharmacist.
We are the supplier of Metformin & GLICLAZIDE also a trader of Metformin & GLICLAZIDE.
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