PHARMA THIRD PARTY CONTRACT MANUFACTURER OF RABEPRAZOLE & LEVOSULPIRIDE
Rabeprazole can be studied as an inhibitor of proton pump which is used for healing gastric problems like acidic stomach & gas. It is also used as the antiulcer compound. Levosulpiride belongs to the Dopamine receptor antagonist, which possesses antidepressant & antipsychotic actions.
Class Proton pump inhibitor & Dopamine receptor antagonist
Mechanism of action
Rabeprazole is an antisecretory compound which functions to suppress the amount of gastric acid by inhibiting the functioning of H+/K+-ATPase system which gets activated in acidic medium. Levosulpiride acts by inhibiting the Dopamine receptor primarily on Dopamine-2 receptor & resulting in prokinetic effects.
Absorption of Rabeprazole -Rapid
Absorption of Levosulpiride-slow
Bioavailability of Rabeprazole - 52%
Bioavailability of Levosulpiride -25-35%
Metabolism of Rabeprazole-Hepatic
Protein binding of Rabeprazole-96.3%
The half-life of Rabeprazole-1-2 hours
The half-life of Levosulpiride-6-8 hours
The combination of Rabeprazole & Levosulpiride is indicated for the gastrointestinal reflux, Indigestion, Intestinal & stomach ulcers, mental disorder, gastric acidity, irritable syndrome bowel, depression & heartburn due to gastric acid.
The adverse reaction of the combination is
Dry & sore throat
Alteration in sexual desire
Neuroleptic malignant syndrome
Caffeine (its metabolism decreases)
Amphetamine (its absorption increases)
Cimetidine (metabolism decreases)
Acetyldigitoxin (side effects increases)
Aluminum glycinate/hydroxide/acetoacetate (serum concentration of Levosulpiride decreases)
Each capsule contains 20mg Rabeprazole of & 75mg of Levosulpiride. The dose recommended is 1-2 capsules per day or as suggested by the healthcare professional.
We are the supplier of Rabeprazole & Levosulpiride & also a trader of Rabeprazole & Levosulpiride.
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