General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF RABEPRAZOLE & LEVOSULPIRIDE

Introduction


Rabeprazole can be studied as an inhibitor of proton pump which is used for healing gastric problems like acidic stomach & gas. It is also used as the antiulcer compound. Levosulpiride belongs to the Dopamine receptor antagonist, which possesses antidepressant & antipsychotic actions. 

Class Proton pump inhibitor & Dopamine receptor antagonist

Mechanism of action

Rabeprazole is an antisecretory compound which functions to suppress the amount of gastric acid by inhibiting the functioning of H+/K+-ATPase system which gets activated in acidic medium. Levosulpiride acts by inhibiting the Dopamine receptor primarily on Dopamine-2 receptor & resulting in prokinetic effects. 

Pharmacokinetics

Absorption of Rabeprazole -Rapid 

Absorption of Levosulpiride-slow

Bioavailability of Rabeprazole - 52%

Bioavailability of Levosulpiride -25-35%

Metabolism of Rabeprazole-Hepatic

Protein binding of Rabeprazole-96.3%

The half-life of Rabeprazole-1-2 hours

The half-life of Levosulpiride-6-8 hours

Excretion-Urinary excretion 

Pharmacological Uses

The combination of Rabeprazole & Levosulpiride is indicated for the gastrointestinal reflux, Indigestion, Intestinal & stomach ulcers, mental disorder, gastric acidity, irritable syndrome bowel, depression & heartburn due to gastric acid. 

Side Effects

The adverse reaction of the combination is 

Dry & sore throat

Abdominal discomfort 

Alteration in sexual desire 

Infections 

Neuroleptic malignant syndrome 

Indigestion 

Muscle weakness

product Interactions

Caffeine (its metabolism decreases) 

Amphetamine (its absorption increases) 

Cimetidine (metabolism decreases)

Acetyldigitoxin (side effects increases) 

Aluminum glycinate/hydroxide/acetoacetate (serum concentration of Levosulpiride decreases)

Dosage

Each capsule contains 20mg Rabeprazole of & 75mg of Levosulpiride. The dose recommended is 1-2 capsules per day or as suggested by the healthcare professional. 

We are the supplier of Rabeprazole & Levosulpiride & also a trader of Rabeprazole & Levosulpiride.

* The following symptoms are suggestive & needs to be confirmed before promoting or coating anywhere & anybody whom so ever. Power2pharma.com & its parent company NEWS pharma Pvt. Ltd. is not responsible for its authenticity.


LEVOSULPIRIDE 75mg, RABEPRAZOLE 20mg SR Capsule ALU-ALU 10*10