General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF METHYLPREDNISOLONE 

Introduction


Methylprednisolone is an Anti-inflammatory corticosteroid has similarities with the hormone produced by the adrenal gland. Methyl Prednisolone Sodium Succinate is the sodium succinate ester of Methyl Prednisolone. It is a synthetic Glucocorticoid with minimal mineralocorticoid activity.

Class

Corticosteroids, Adrenals

Mechanism of action

Glucocorticoids modify the body’s immune responses to diverse stimuli, transcription & protein synthesis & then at the site of inflammation they inhibit leukocyte infiltration. Methyl Prednisolone is a potent anti-inflammatory steroid with greater anti-inflammatory potency than prednisolone. It works to treat people with low levels of Corticosteroids by replacing steroids. It also reduces swelling & redness by changing the way of working of the immune system. 

Pharmacokinetics

The intravenous injection of methylprednisolone sodium succinate demonstrable effects is evident within one hour & persists for a variable period.

Absorption-Rapidly absorbed

Bioavailability of Methylprednisolone-80-99%

Protein binding of Methylprednisolone-78%

The half-life of Methylprednisolone—3 hours 

Excretion of the administered dose-within 12 hours

Pharmacological uses 

Methylprednisolone is useful in Control of severe or incapacitating allergic conditions, Treatment of Asthma, Atopic dermatitis, Contact Dermatitis, product Hyper Sensitivity Reactions, Perennial or Seasonal Allergic rhinitis, Serum Sickness, Transfusion Reactions, Herpetiformis, Mycosis Fungoides, Ulcerative Colitis acquired (autoimmune) Hemolytic Anemia, Congenital Hypoplastic Anemia (Diamond- Black fan Anemia), Idiopathic Thrombocytopenic purpura in adults, Tuberculosis Meningitis, Leukemias & Lymphomas, Ocular Inflammatory Conditions, To induce diuresis, Rheumatoid Arthritis & Ankylosing spondylitis.

Side effects

Elevation of Blood Pressure

Salt & Water retention

Increased Excretion of Potassium

Increase Calcium Excretion

Hypertension

product interaction 

Aminoglutethimide

Amphotericin B injection & Potassium-depleting agent

Hepatic Enzyme Inhibitors (Ketoconazole)

Aceclofenac & Acetylsalicylic acid

Bismuth subcitrate or subnitrate 

Dosage

Intramuscular- 0.03-0.2 mg/kg or 1-6.25 mg/m2 IM 1-2 times daily

30 mg/kg administered intravenously over at least 30 minutes.

We are the supplier of Methylprednisolone Sodium Succinate & also a trader of Methylprednisolone Sodium Succinate.

* The following symptoms are suggestive & needs to be confirmed before promoting or coating anywhere & anybody whom so ever. Power2pharma.com & its parent company NEWS pharma Pvt. Ltd. is not responsible for its authenticity.


METHYLPREDNISOLONE 4mg Tablet ALU-ALU 10*10