General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF RABEPRAZOLE & ACECLOFENAC

Introduction


Rabeprazole is classified as proton pump inhibitor which possesses antiulcer product by reducing the gastric acid in the stomach. It is administered as a proproduct. Aceclofenac belongs to the group of Non-steroidal anti-inflammatory products & it also possesses analgesic actions. 

Class Proton pump inhibitor & NSAIDs.

Mechanism of action

Rabeprazole is an antisecretory compound works to minimize the production of acid in the stomach by inhibiting H+/K+ATPase system at the gastric parietal cell. Aceclofenac shows anti-inflammatory action by inhibiting cyclooxygenase enzyme which is used for increasing the rate of reaction of prostaglandin production a reason behind inflammation. 

Pharmacokinetics

Absorption of combination-Rapid 

Bioavailability of Rabeprazole - 52%         

Bioavailability of Aceclofenac-100%

Metabolism of Rabeprazole-Hepatic

Protein binding of Rabeprazole-96.3%

Protein binding of Aceclofenac -99%

The half-life of Rabeprazole-1-2 hours

The half-life of Aceclofenac -4 hours 

Excretion-Urinary excretion 

Pharmacological Uses

The combination of Rabeprazole & Aceclofenac is used for the treatment of Rheumatoid arthritis, Ankylosing spondylitis, gastric acidity, stomach & intestinal ulcers, osteoarthritis, gastric acidity & also lumbago & Zollinger-Ellison syndrome. 

Side Effects

Abdominal disturbance

Urticaria

Nausea & Dyspepsia

Anaphylaxis 

Dry & sore mouth 

Blurred vision 

Blood disorder

Insomnia 

product Interactions

Itraconazole & Ketoconazole 

Antipyrine (its metabolism decreases) 

Atorvastatin (Side effects increases) 

Chloramphenicol (decreases metabolism of Rabeprazole)

Amiodarone (decreases metabolism of Aceclofenac)

Dosage

Each capsule contains 20mg of Rabeprazole & 200mg of Aceclofenac. The recommended dose is one capsule per day. 

We are the supplier of Rabeprazole & Aceclofenac & also a trader of Rabeprazole & Aceclofenac.

* The following symptoms are suggestive & needs to be confirmed before promoting or coating anywhere & anybody whom so ever. Power2pharma.com & its parent company NEWS pharma Pvt. Ltd. is not responsible for its authenticity.


RABEPRAZOLE 20mg, ACECLOFENAC 200mg SR Capsule ALU-ALU 10*10