General Products

PHARMA THIRD PARTY CONTRACT MANUFACTURER OF RABEPRAZOLE & DOMPERIDONE

Introduction

Rabeprazole can be studied as an inhibitor of proton pump which is used for healing gastric problems like acidic stomach & gas. It is also used as the antiulcer compound. Domperidone can be studied as an inhibitor of Dopamine receptor which is used as an antiemetic compound, for the release of prolactin & increases the movement in the gastrointestinal tract. 

Class Proton pump inhibitor & Dopamine receptor antagonist

Mechanism of action

Rabeprazole is an antisecretory compound which functions to suppress the amount of gastric acid by inhibiting the functioning of H+/K+-ATPase system which gets activated in acidic medium. Domperidone function is to promote gastric emptying by increasing lower esophageal sphincter pressure for GIT movement & to control vomiting. It antagonizes the action of dopamine receptor (D2 & D3) at gastric level & chemoreceptor trigger. 

Pharmacokinetics

Absorption of combination-Rapid 

Bioavailability of Rabeprazole - 52%

Bioavailability of Domperidone-15%

Metabolism of Rabeprazole-Hepatic

Protein binding of Rabeprazole-96.3%

Protein binding of Domperidone-91-93%

The half-life of Rabeprazole-1-2 hours

The half-life of Domperidone-7 hours

Excretion-Urinary excretion 

Pharmacological Uses

The combination of Rabeprazole & Domperidone is used for duodenal ulcer, Nausea & vomiting, Gastroesophageal reflux disease & stomach acid & gas & stomach ulcers. 

Side Effects

Constipation

Abdominal discomfort

Sleeplessness

A Headache 

Blurred vision

Dry mouth 

Dizziness

product Interactions

Digoxin & Ketoconazole (pH-dependent interaction) 

Chloramphenicol (decreases metabolism of Rabeprazole)

Aceclofenac, Acetaminophen (its metabolism decreases)

Caffeine (its metabolism decreases) 

Amphetamine (its absorption increases) 

Cimetidine (metabolism decreases)

Dosage

Each capsule/tablet contains 20mg Rabeprazole of & 30mg of Domperidone/20mg Rabeprazole of & 10mg of Domperidone. The dose recommended is 1-2 capsules per day or as suggested by the healthcare professional. 

We are the supplier of Rabeprazole & Domperidone & also a trader of Rabeprazole & Domperidone.

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